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New frontiers in myocardial protection: harnessing the heart's endogenous protective systems
1Surgical Research Center, University of Connecticut School of Medicine, Farmington, USA.
Connecticut Medicine
|July 1, 1995
Abstract:
Researchers have continued to search for therapeutic agents to protect the heart during ischemia and reperfusion. Recent studies have suggested that harnessing the heart's endogenous systems for self-preservation may provide improved protection from ischemic injury. Two such phenomena, preconditioning and heat-shock protein synthesis, have been shown to uniformly reduce myocardial damage. This review highlights the newest research in myocardial protective strategies and suggests avenues of future investigation.