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Recurrent Salmonella enteritidis sepsis and hepatic tuberculosis
M Trauner1, E Grasmug, R E Stauber
1Department of Medicine, Karl Franzens University, Graz, Austria.
Gut
|July 1, 1995
Summary
Recurrent Salmonella sepsis was successfully treated with high-dose ciprofloxacin and ceftriaxone. Underlying tuberculosis was identified as the cause of granulomatous hepatitis and recurrent infections.
Area of Science:
- Infectious Diseases
- Hepatology
- Microbiology
Background:
- Recurrent Salmonella sepsis presents a significant therapeutic challenge.
- Granulomatous hepatitis can complicate severe infections and lead to prolonged cholestasis.
Observation:
- A 33-year-old woman experienced recurrent Salmonella enteritidis sepsis, refractory to multiple antibiotics.
- She developed prolonged intrahepatic cholestasis attributed to granulomatous hepatitis.
- Mycobacterial DNA detected in liver biopsy led to diagnosis of tuberculosis.
Findings:
- A combination of high-dose ciprofloxacin and ceftriaxone achieved sustained remission of Salmonella sepsis.
- Tuberculosis was identified as the underlying cause of granulomatous hepatitis and recurrent Salmonella infections.
- Polymerase chain reaction (PCR) for mycobacterial DNA proved crucial for diagnosing tuberculosis when standard methods failed.
Implications:
- Combination therapy with ciprofloxacin and ceftriaxone offers a promising treatment for recurrent Salmonella sepsis.
- Tuberculosis should be considered in patients with recurrent Salmonella sepsis and unexplained granulomatous hepatitis.
- PCR for mycobacterial DNA is a valuable tool in diagnosing granulomatous liver disease of unclear etiology.
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