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Primary diffuse leptomeningeal oligodendroglioma. Case report

R Chen1, D R Macdonald, D A Ramsay

  • 1Department of Clinical Neurological Sciences, Victoria Hospital, University of Western Ontario, Canada.

Journal of Neurosurgery
|October 1, 1995
PubMed
Summary

A rare diffuse primary leptomeningeal oligodendroglioma presented in a teen with increased intracranial pressure. Postmortem findings supported a theory of ectopic glial tissue origin for leptomeningeal gliomas.

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Area of Science:

  • Neuro-oncology
  • Neuropathology

Background:

  • Diffuse primary leptomeningeal oligodendroglioma is a rare and aggressive brain tumor.
  • Leptomeningeal gliomas are challenging to diagnose and treat, often presenting with diffuse spread.

Observation:

  • A 17-year-old female presented with symptoms of raised intracranial pressure and hydrocephalus.
  • Imaging revealed a cystic oligodendroglioma in the suprasellar cistern with leptomeningeal spread to the spinal cord.

Findings:

  • The tumor exhibited minimal response to radiotherapy and chemotherapy.
  • Postmortem examination confirmed diffuse meningeal infiltration without an intraparenchymal origin.
  • Glial heterotopias were observed, supporting the theory of ectopic glial origin in the subarachnoid space.

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Implications:

  • This case highlights the aggressive nature and poor prognosis of diffuse primary leptomeningeal oligodendroglioma.
  • Findings suggest leptomeningeal gliomas may arise from ectopic glial tissue, impacting future diagnostic and therapeutic strategies.
  • Further research into the pathogenesis of leptomeningeal gliomas is warranted.