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Updated: Aug 24, 2026

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
Published on: March 22, 2018
[A method for inducing standardized spiral fractures of the tibia in the animal experiment]
R Seibold1, U Schlegel, J Cordey
1Chirurgische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Abstract:
A method for the deliberate weakening of cortical bone has been developed on the basis of an already established technique for creating butterfly fractures. It enables one to create the same type of fracture, i.e., a spiral fracture, every time. The fracturing process is recorded as a force-strain curve. The results of the in vitro investigations form a basis for the preparation of experimental tasks aimed at demonstrating internal fixation techniques and their influence on the vascularity of the bone in simulated fractures. Animal protection law lays down that this fracture model must not fail in animal experiments.

