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In vitro elution of ofloxacin from a bioabsorbable polymer
L Nie1, D P Nicolau, C H Nightingale
1Department of Orthopedic Surgery, Hartford Hospital, Connecticut 06102, USA.
Acta Orthopaedica Scandinavica
|August 1, 1995
Summary
Bioabsorbable polymer composites offer an alternative to polymethylmethacrylate (PMMA) beads for local antibiotic delivery. Ofloxacin release varied based on polymer composition and bead size over 60 days.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Polymethylmethacrylate (PMMA) beads are used for local antimicrobial delivery but require a second surgery for removal.
- Bioabsorbable polymers present a potential alternative to reduce the need for secondary procedures.
Purpose of the Study:
- To investigate the release characteristics of ofloxacin from bioabsorbable lactide: glycolide polymer composites.
- To compare the drug release profiles of different polymer compositions and bead sizes.
Main Methods:
- Ofloxacin (10 mg) was incorporated into 30 mg and 50 mg beads of two lactide: glycolide polymer ratios (85:15 and 50:50).
- An elution method was used to study drug release over 60 days at 37°C.
Main Results:
- Composites with 85:15 polymer (both 30 mg and 50 mg sizes) released approximately 50% of the incorporated ofloxacin over 60 days.
- Composites with 50:50 polymer (both 30 mg and 50 mg sizes) released nearly all of the incorporated ofloxacin within 60 days.
Conclusions:
- The release rate of ofloxacin from lactide: glycolide polymer composites is dependent on the polymer's molar ratio.
- Bioabsorbable polymer composites demonstrate tunable drug release profiles for local antimicrobial delivery.