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Updated: Aug 13, 2026

A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels
Published on: April 24, 2012
Molecular biology of somatostatin receptors
Abstract:
The neuropeptide somatostatin (SRIF) has diverse physiological actions in the brain and endocrine organs. A family of SRIF receptors has recently been cloned that may mediate the distinct biological effects of SRIF. These receptors have a high degree of amino acid sequence similarity among themselves, but their sequences are different from any other receptors, indicating that they represent a distinct neurotransmitter receptor subfamily. The availability of the cloned receptors will now allow for detailed structure-function analysis of SRIF receptors and will facilitate development of subtype-selective agonists and antagonists that could be useful in the treatment of central nervous system and endocrine disorders.
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