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Long-term transfer-factor treatment for multiple sclerosis

T Fog, L Pedersen, N E Raun

    Lancet (London, England)
    |April 22, 1978
    PubMed
    Summary
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    Transfer factor treatment in multiple sclerosis patients temporarily restored lymphocyte reactivity but did not halt nerve tissue degeneration. This study highlights limited efficacy for this immunomodulatory approach in multiple sclerosis.

    Area of Science:

    • Immunology
    • Neurology
    • Clinical Trials

    Background:

    • Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.
    • Immunomodulatory therapies are explored to manage MS progression.

    Purpose of the Study:

    • To evaluate the efficacy of transfer factor from normal donors in treating multiple sclerosis.
    • To assess the impact of transfer factor on lymphocyte reactivity and neurological degeneration in MS patients.

    Main Methods:

    • A 13-month, double-blind, placebo-controlled study involving 16 patients with multiple sclerosis.
    • Treatment with transfer factor derived from random normal donors versus a placebo.

    Main Results:

    • Transfer factor treatment resulted in a temporary restoration of lymphocyte reactivity to measles virus antigen.

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  • No significant difference was observed in the arrest of nerve tissue degeneration between the transfer factor and placebo groups.

    • Conclusions:

    • Transfer factor demonstrated a transient immunomodulatory effect in multiple sclerosis patients.
    • The treatment did not provide a sustained clinical benefit by preventing neurological damage in MS.