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Platelet aggregability in patients with a VVI pacemaker

S Fazio1, A Cittadini, D Sabatini

  • 1Department of Internal Medicine, 2nd Medical School, Federico II University, Naples, Italy.

Pacing and Clinical Electrophysiology : PACE
|February 1, 1993
PubMed
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Patients with VVI pacemakers show increased platelet activity, indicated by higher beta-thromboglobulin levels and abnormal platelet aggregation responses. This suggests a higher risk of blood clots in VVI pacemaker patients.

Area of Science:

  • Cardiology
  • Hematology
  • Biomedical Engineering

Background:

  • Studies suggest a higher incidence of thromboembolic events in patients with Ventricular Ventricular Inhibited (VVI) pacemakers.
  • Anticoagulant or antiplatelet therapy may reduce these events, implying increased platelet thrombi formation in VVI patients.

Purpose of the Study:

  • To investigate platelet aggregability in patients with VVI pacemakers.
  • To compare platelet activation markers and aggregation responses between VVI patients and healthy controls.

Main Methods:

  • Assessed plasma levels of beta-thromboglobulin (beta-Tg) and platelet factor 4 (PF4).
  • Measured platelet aggregation induced by ADP, collagen, epinephrine, and arachidonic acid.
  • Compared these parameters in ten VVI patients and ten age- and sex-matched controls.

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Main Results:

  • VVI patients exhibited significantly elevated plasma beta-Tg levels (86 +/- 24 vs 24 +/- 13 ng/mL; P < 0.001).
  • Platelet aggregation studies revealed abnormal maximal amplitude, slope, and lag time in VVI patients.
  • Maximal aggregation amplitude was significantly higher in VVI patients across multiple agonists (ADP, collagen, epinephrine, arachidonic acid).

Conclusions:

  • Findings strongly suggest increased platelet activity in patients with VVI pacemakers.
  • Elevated platelet aggregability may contribute to the increased thromboembolic risk observed in VVI patients.
  • Further research into antiplatelet strategies for VVI patients is warranted.