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Effect of captopril on postischemic myocardial expansion
C Eng1, B J Weil, E H Sonnenblick
1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Journal of Cardiovascular Pharmacology
|April 1, 1993
Summary
Captopril did not preserve systolic function in myocardial stunning but prevented abnormal diastolic expansion of postischemic myocardium. This finding is crucial for understanding captopril
Area of Science:
- Cardiovascular Physiology
- Pharmacology
- Myocardial Ischemia Research
Background:
- Myocardial stunning is a post-ischemic dysfunction.
- Diastolic expansion of stunned myocardium can occur.
- Captopril is an angiotensin-converting enzyme inhibitor.
Purpose of the Study:
- To assess captopril's effects on systolic function and diastolic expansion in myocardial stunning.
- To investigate captopril's impact in an open-chest multiple occlusion model.
Main Methods:
- An open-chest multiple occlusion model was used.
- Captopril was administered as a bolus and infusion.
- Systolic function and end-diastolic length were measured by sonomicrometry.
Main Results:
- Captopril did not preserve systolic function in stunned myocardium.
- Captopril abolished the abnormal 5-7% end-diastolic length expansion in stunned myocardium.
- Mean aortic pressure was lower in the captopril group.
Conclusions:
- Captopril has no effect on preserving systolic function during myocardial stunning.
- Captopril favorably impacts diastolic dilation and expansion of postischemic myocardium.
- These findings suggest a specific role for captopril in managing post-ischemic myocardial mechanics.