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Related Experiment Videos

Effect on verapamil on ventricular function: studies in denervated human heart

D S Schulman1, B A Herman, T Edwards

  • 1Department of Internal Medicine, University of Pittsburgh School of Medicine, Pennsylvania.

Journal of Cardiovascular Pharmacology
|April 1, 1993
PubMed
Summary

Verapamil directly reduces heart contractility (inotropic effect) and heart rate (chronotropic effect) in denervated ventricles. This study clarifies verapamil

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Area of Science:

  • Cardiology
  • Pharmacology
  • Physiology

Background:

  • Verapamil's effects on heart function are complex, involving direct myocardial actions, vasodilation, and sympathetic nervous system responses.
  • Understanding direct myocardial effects requires isolating them from reflex sympathetic stimulation.

Purpose of the Study:

  • To determine the direct impact of verapamil on human ventricular function.
  • To assess verapamil's effects independent of sympathetic nervous system reflexes.

Main Methods:

  • Studied 13 heart transplant recipients with denervated ventricles.
  • Administered intravenous verapamil and monitored hemodynamics and radionuclide angiograms.
  • Analyzed left ventricular (LV) systolic function using pressure-volume relations (SPVR) and diastolic function via peak filling rate (PFR).

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Main Results:

  • Verapamil decreased blood pressure and heart rate, increasing right atrial and pulmonary artery wedge pressures.
  • LV ejection fraction decreased, indicating negative inotropic effects.
  • No significant change in peak filling rate (PFR) was observed, suggesting minimal diastolic impact.

Conclusions:

  • In denervated ventricles, verapamil exhibits direct negative chronotropic and inotropic effects.
  • Verapamil has minimal direct impact on diastolic function as measured by PFR in this population.