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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Antibodies developing against a single recombinant interferon protein may neutralize many other interferon-alpha

C M Brand1, L Leadbeater, G Bellati

  • 1Biotechnology Development, Wellcome Research Laboratories, Beckenham, Kent, England.

Journal of Interferon Research
|April 1, 1993
PubMed
Summary

High levels of neutralizing antibodies developed in three hepatitis C patients receiving recombinant interferon-alpha 2a (rIFN-alpha 2a) therapy, leading to clinical relapse and resistance to further treatment.

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