Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypertonic solutions in the intensive care unit]

L Hannemann1, R Korell, A Meier-Hellmann

  • 1Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der F.U. Berlin.

Zentralblatt Fur Chirurgie
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Sepsis incidence in Germany and worldwide : Current knowledge and limitations of research using health claims data].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2021
Same author

COVID-19 reinforces the need to improve sepsis care resources in Africa.

Infection·2021
Same author

Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis.

Intensive care medicine·2020
Same author

[S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

[S3 guideline sepsis-prevention, diagnosis, treatment, and aftercare : Summary of the strong recommendations].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2020
Same author

Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany.

Intensive care medicine·2018
Same journal

[Treatment of Vocal Fold Paralysis].

Zentralblatt fur Chirurgie·2026
Same journal

Zentralblatt fur Chirurgie·2026
Same journal

Predictive Factors for Mediastinal Lymph Node Metastases in Patients with Non-small Cell Lung Cancer, as Detected by Video-assisted Mediastinoscopic Lymphadenectomy.

Zentralblatt fur Chirurgie·2026
Same journal

[Robotic Management of a Bile Leak After Cholecystectomy Caused by an Aberrant Bile Duct of the Hepatic Segments, Using a Combined Biliodigestive Anastomosis Incorporating the Cystic Duct Stump].

Zentralblatt fur Chirurgie·2026
Same journal

[Microvascular Reconstruction of the Laryngotracheal Junction].

Zentralblatt fur Chirurgie·2026
Same journal

[Evaluation of Multimodal Perioperative Care Pathway Supported by a Patient-facing Mobile App in Colorectal Surgery - First Clinical Experience and Patient Satisfaction].

Zentralblatt fur Chirurgie·2026
See all related articles

Hypertonic saline (HTS) with hydroxyethylstarch (HAES) significantly increased oxygen delivery (DO2) in critically ill septic patients. This resuscitation strategy improved oxygen consumption (VO2) without evidence of oxygen debt.

Area of Science:

  • Critical Care Medicine
  • Resuscitation Science
  • Hemodynamics

Background:

  • Small volume resuscitation with hypertonic saline (HTS) and colloids stabilizes oxygen transport in hemorrhagic shock.
  • HTS improves tissue oxygenation by enhancing cardiac preload, reducing afterload, and mitigating microcirculatory edema.

Purpose of the Study:

  • To investigate if HTS combined with hydroxyethylstarch (HAES) significantly increases oxygen delivery (DO2) and oxygen consumption (VO2) in hyperdynamic critically ill patients.
  • To compare the effects in septic versus non-septic critically ill patients.

Main Methods:

  • 41 critically ill patients (20 septic, 21 non-septic) were studied.
  • Infusion of 2-4 ml/kg of 7.5% HTS in 6% HAES over 15 minutes was administered once hyperdynamic circulation (DO2 > 700 ml/min/m2) was achieved.

Related Experiment Videos

Main Results:

  • Septic patients showed a significant 14% increase in DO2 (p < 0.001).
  • VO2 increased by 7% (p < 0.05) calculated via Fick method; a 4% increase was observed via respiratory gases (n.s.).
  • Non-septic patients exhibited similar increases in DO2 and VO2, with no significant intergroup differences. Oxygen extraction ratio increased by approximately 10% in both groups.

Conclusions:

  • HTS/HAES resuscitation effectively increases DO2 and VO2 in hyperdynamic septic patients.
  • The observed increase in VO2 is not indicative of a significant tissue oxygen debt.
  • This resuscitation strategy appears safe and effective in both septic and non-septic critically ill patients.