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Related Experiment Videos

Human hair keratins

J Yu1, D W Yu, D M Checkla

  • 1Ronald O. Perelman Department of Dermatology, N.Y.U. Medical Center, N.Y. 10016.

The Journal of Investigative Dermatology
|July 1, 1993
PubMed
Summary
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Human hair keratins, distinct from epidermal types, possess higher cysteine for structural toughness. Genetic studies reveal significant expression variation without apparent phenotypic changes, enhancing our biologic understanding.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Dermatology

Background:

  • Human hair keratins are intermediate filament proteins, recently understood biologically.
  • They differ significantly from epidermal keratins, necessitating separate classification (type Ia/IIa vs. Ib/IIb).

Purpose of the Study:

  • To provide a basic biologic perspective on human hair keratins.
  • To detail molecular characteristics and expression variations.

Main Methods:

  • Analysis of human hair keratin gene studies.
  • Elucidation of amino acid sequence data for type Ia hair keratin.
  • Pedigree studies to assess expression variation.

Main Results:

  • Human hair keratins have higher cysteine content (7.6%) than epidermal keratins (2.9%), enabling disulfide bonding for structural durability.

Related Experiment Videos

  • Hair keratins are not exclusively found in hair.
  • Significant variation in human hair keratin expression is tolerated without obvious phenotypic changes.

    • Conclusions:

    • A foundational understanding of human hair keratins has been established and is evolving.
    • The unique properties of hair keratins contribute to tissue structure and durability.
    • Genetic variability in hair keratin expression has minimal observable impact on hair phenotype.