[Age-related changes in Bruch's membrane of the senescence accelerated mouse]

We studied pathological changes in Bruch's membrane of Senescence Accelerated Mouse (SAM) P/1. Tannic acid was used to demonstrate collagen fibers and microfibrils in Bruch's membrane. With aging, thickening of Bruch's membrane, especially thickening of the basement membrane of the choriocapillaris, was remarkable. The distance between collagen fibers also became wider, and many more fine fibrils appeared around each collagen fibril with aging. These changes were observed mor in the posterior area than in the periphery.