[Effects of granulocyte-colony stimulating factor on hematogram examinations]

Effects of granulocyte-colony stimulating factor (G-CSF) on hemograms were studied in the leukopenic phase after chemotherapy on patients with solid malignant tumors and lymphocytic malignancies. The samples were from patients with solid malignant tumors (solid tumor group) and from those with lymphocytic malignancies (lymphocytic malignancy group). In the control group, the increase rate and the decrease rate of the white blood cell count were 1.48 and 0.67, respectively. With the administration of G-CSF, they were 4.99 and 0.29 in the malignant tumor group, and 11.83 and 0.19 changes beyond the range of physiologic fluctuations with the administration of G-CSF. In term of increasing rate, immature myeloid cells were increased more remarkably than mature neutrophil by administration of G-CSF, indicating that the target cells of G-CSF are immature cells, and the increase of immature cells is responsible for the increase of the whole white blood cell count. Though immature myeloid cells with atypical morphology were rarely detected in the solid tumor group, they were observed more frequently in the lymphocytic malignancy group. In this study, we stress that the information about the history of G-CSF administration is indispensable for quality control of hemogram examinations.