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Cutaneous cylindroma with malignant transformation
A L Gerretsen1, S C van der Putte, W Deenstra
1Department of Dermatology, University Hospital Utrecht, The Netherlands.
Cancer
|September 1, 1993
Summary
Malignant cutaneous cylindroma, a rare cancer, is more aggressive in its multiple tumor form. This aggressive carcinoma shows destructive growth and metastasis, requiring careful histopathologic evaluation.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Malignant cutaneous cylindroma is an exceptionally rare neoplasm.
- It presents as either a solitary lesion or part of an autosomal dominant inherited multiple tumor syndrome.
Observation:
- Two new cases of malignant cutaneous cylindroma within a single family afflicted with multiple cylindromas are presented.
- Clinical and histopathologic data were compared with 26 previously reported cases.
Findings:
- Malignant tumors exhibited rapid growth, ulceration, or bleeding, distinguishing them from benign counterparts.
- Histopathology revealed a well-differentiated carcinoma in one case and a poorly differentiated tumor with lymph node metastasis in the other.
- Metastasis led to patient mortality 2.5 years post-diagnosis.
Implications:
- Malignant cutaneous cylindroma appears more prevalent in the multiple tumor variant.
- This aggressive carcinoma demonstrates a propensity for local invasion and distant metastasis.