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[Granulocyte-colony stimulating factor and clinical laboratory]
T Orita1, K Kitamura, A Ohkubo
1Department of Laboratory Medicine, Faculty of Medicine, University of Tokyo.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 1, 1993
Summary
Granulocyte-colony stimulating factor (G-CSF) significantly alters white blood cell counts and morphology, impacting laboratory test precision. Clinical staff should report G-CSF use to ensure accurate interpretation of blood cell analysis.
Area of Science:
- Hematology
- Oncology
- Laboratory Medicine
Background:
- Granulocyte-colony stimulating factor (G-CSF) is used to manage leukocytopenia post-chemotherapy.
- This study investigates G-CSF effects in solid tumor and lymphocytic malignancy patients.
Observation:
- G-CSF administration caused substantial increases in white blood cell counts, exceeding physiologic ranges.
- A marked rise in immature leukocytes and increased morphological abnormalities were observed.
Findings:
- G-CSF significantly impacts white blood cell counts and morphology, affecting routine laboratory blood tests.
- The study identified c-kit-positive cells in peripheral blood post-G-CSF, suggesting potential for stem cell transplantation.
Implications:
- Accurate interpretation of blood cell counts requires knowledge of prior G-CSF treatment.
- G-CSF may mobilize stem cells, showing promise for peripheral stem cell transplantation efficacy.