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AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease
B Kremer1, S J Tallaksen-Greene, R L Albin
1Department of Medical Genetics, University of British Columbia, Canada.
Neurology
|August 1, 1993
Abstract:
The excitatory amino acid (EAA) hypothesis of neuronal loss in Huntington's disease predicts that structures that show neuronal loss and gliosis will contain receptor-bearing neurons. In accordance with this hypothesis, the hypothalamic lateral tuberal nucleus, severely affected in Huntington's disease, showed a high density of NMDA and AMPA binding sites in four normal subjects.