A study of NADPH diaphorase-positive axonal plexuses in the human temporal cortex

Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry was used to study the morphology of labeled axonal plexuses in the human lateral temporal cortex. Strongly stained non-pyramidal neurons and a dense NADPH diaphorase-positive network of fibers were observed in all cortical layers. Certain stained fibers are found to give rise to basket-like formations. Notably other fibers seem to innervate small blood vessels. In addition, numerous blood vessels show a punctate labeling over their surfaces. These findings provide new morphological and chemical details of the axonal innervation of the human neocortex.