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[Peripheral blood stem cell transfusion for a patient with RAEB-T]
H Fujii1, H Nakagawa, Y Sonoda
1Third Department of Internal Medicine, Kyoto First Red Cross Hospital.
Summary
A patient with refractory anemia with excess blasts in transformation (RAEB-T) achieved complete remission for 15 months after peripheral blood stem cell transplantation (PBSCT). This case highlights PBSCT as an effective treatment option for RAEB-T.
Area of Science:
- Hematology
- Oncology
- Stem Cell Transplantation
Background:
- Refractory anemia with excess blasts in transformation (RAEB-T) is an aggressive hematologic malignancy.
- Treatment options for RAEB-T are limited, with high relapse rates.
- Peripheral blood stem cell transplantation (PBSCT) is a potential curative therapy.
Observation:
- A 51-year-old male diagnosed with RAEB-T presented with abnormal blood counts and myeloblasts in peripheral blood and bone marrow.
- The patient initially achieved complete remission with chemotherapy (low dose Ara-C, BHAC-VEP regimen).
- Following high-dose Ara-C, PBSCT was performed after leukapheresis and cryopreservation of stem cells.
Findings:
- The conditioning regimen included busulfan, cyclophosphamide, and rG-CSF.
- Engraftment was achieved at 17 days for neutrophils and 63 days for platelets.
- The patient has maintained complete remission for 15 months post-PBSCT.
Implications:
- This case demonstrates the efficacy of PBSCT in achieving long-term remission in RAEB-T.
- PBSCT should be considered a viable therapeutic strategy for patients with RAEB-T.
- Further research into optimizing PBSCT protocols for RAEB-T is warranted.