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Clinical experience with an endobronchial implant
B R Marsh1, D P Colvin, E S Zinreich
1Johns Hopkins University School of Medicine, Baltimore, MD.
Radiology
|October 1, 1993
Summary
This study shows an implantable iodine-125 brachytherapy capsule is safe for endobronchial carcinoma. The treatment achieved tumor regression and symptomatic relief in patients with recurrent or inoperable lung cancer.
Area of Science:
- Oncology
- Medical Devices
- Radiotherapy
Background:
- Endobronchial carcinoma presents treatment challenges, especially in recurrent or inoperable cases.
- Bronchoscopic interventions offer minimally invasive therapeutic options.
Purpose of the Study:
- To evaluate the clinical safety and efficacy of a novel implantable iodine-125 brachytherapy capsule for endobronchial tumors.
- To assess treatment outcomes including tumor response, symptom relief, and survival.
Main Methods:
- A capsule containing iodine-125 seeds was bronchoscopically implanted in 12 patients with recurrent or inoperable lung cancer.
- Patients received a median dose of 4,500 cGy at a 1-cm radius.
Main Results:
- No acute toxicities were observed during treatment.
- Complete tumor regression occurred in 5 patients, partial regression in 4.
- Symptomatic relief was noted for dyspnea, cough, and hemoptysis; median survival was 6 months.
Conclusions:
- The implantable brachytherapy capsule is a safe and effective treatment modality.
- This approach shows promise for managing endobronchial malignancies unresponsive to other therapies.