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Published on: November 10, 2014
Clinical experience with an endobronchial implant
B R Marsh1, D P Colvin, E S Zinreich
1Johns Hopkins University School of Medicine, Baltimore, MD.
Purpose:
To report clinical experience with an implantable capsule for treating endobronchial carcinoma by means of bronchoscopic insertion and retrieval.
Materials And Methods:
The capsule consists of a plastic cylinder containing high-activity iodine-125 seeds and four restraining legs. Twelve patients with recurrent (n = 11) or inoperable carcinoma (n = 1) received a median dose of 4,500 (range, 2,633-6,299) cGy at a 1-cm radius from the center of the implant.
Results:
No acute toxicities were observed. Five patients had complete regression of the endobronchial tumor, evidenced at bronchoscopy 2 months after therapy, and four patients had partial regression. Three patients failed to return for bronchoscopy. Symptomatic relief was achieved in eight of 10 patients with dyspnea, four of nine with cough, and two of three with hemoptysis. The median survival of the 12 patients was 6 months. The actuarial 1-year survival rate was 25%.
Conclusion:
This capsule is safe and efficacious in treating recurrent or inoperable carcinoma of the lung.
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