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Related Experiment Videos

E-selectin expression in human cardiac grafts with cellular rejection

M D Allen1, T O McDonald, V E Himes

  • 1Division of Cardiothoracic Surgery, University of Washington, Seattle 98195.

Circulation
|November 1, 1993
PubMed
Summary

E-selectin is expressed in cardiac allograft rejection, potentially aiding lymphocyte recruitment. Its expression may indicate early-stage rejection, alongside VCAM-1, which is more prominent in later stages.

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Area of Science:

  • Immunology
  • Transplantation Biology
  • Cardiovascular Research

Background:

  • E-selectin expression is observed in lymphocytic infiltration in skin and synovium.
  • The role of E-selectin in cardiac graft rejection remained unclear.

Purpose of the Study:

  • To investigate E-selectin expression in cardiac allograft rejection.
  • To determine the correlation between E-selectin expression and the severity of rejection.

Main Methods:

  • Analysis of 195 human posttransplant cardiac biopsy specimens.
  • Immunoreaction with antibodies to E-selectin and VCAM-1.
  • Blinded grading of cardiac graft rejection.

Main Results:

  • E-selectin expression frequency increased with rejection severity (11% no rejection, 36% mild, 58% moderate).

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  • VCAM-1 expression also correlated strongly with rejection severity (11% no rejection, 37% mild, 85% moderate).
  • E-selectin expression was found early in rejection, while VCAM-1 expression was more common in established or resolving rejection.

    • Conclusions:

    • E-selectin is expressed during cardiac allograft rejection.
    • E-selectin may contribute to lymphocyte recruitment into the transplanted heart.
    • E-selectin expression appears to be an early marker of cardiac allograft rejection.