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Nerve growth factor and nociception

G R Lewin1, L M Mendell

  • 1Dept of Neurobiology and Behavior, SUNY at Stony Brook 11794.

Trends in Neurosciences
|September 1, 1993
PubMed
Summary
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Nerve growth factor (NGF) is crucial for the survival and development of nociceptive sensory neurons. In adulthood, NGF links inflammation to hyperalgesia, specifically interacting with these neurons.

Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Nerve growth factor (NGF) is traditionally viewed as essential for neuronal survival and phenotype maintenance.
  • Its role in both peripheral and central nervous system development is well-established.

Purpose of the Study:

  • To investigate the specific roles of NGF in nociceptive sensory neuron development and function across different life stages.
  • To explore the adult physiological function of NGF, particularly its connection to pain signaling.

Main Methods:

  • Utilized physiological techniques to examine NGF's impact on nociceptive sensory neurons.
  • Focused on developmental (in utero, early postnatal) and adult physiological contexts.

Main Results:

  • Nociceptive sensory neurons require NGF for survival during prenatal development.

Related Experiment Videos

  • Postnatally, NGF is essential for phenotypic development but not survival.
  • In adulthood, NGF acts as a mediator between inflammation and hyperalgesia.

    • Conclusions:

    • NGF plays distinct, stage-specific roles in nociceptive sensory neuron development and function.
    • The function of NGF evolves from a survival factor in development to a modulator of pain in adulthood.
    • NGF consistently targets nociceptive sensory neurons throughout an organism's life.