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Long QT syndrome during high-dose cisapride
S Bran1, W A Murray, I B Hirsch
1Veterans Affairs Medical Center, Seattle.
Archives of Internal Medicine
|April 10, 1995
Summary
High doses of cisapride, a gastrointestinal prokinetic drug, can cause serious heart rhythm problems. This case highlights the risks of acquired QT prolongation and ventricular tachycardia with cisapride use.
Area of Science:
- Cardiology
- Pharmacology
- Gastroenterology
Background:
- Cisapride is a widely prescribed gastrointestinal prokinetic agent.
- It is commonly used for treating diabetic gastroparesis and other motility disorders.
Observation:
- A patient developed acquired QT prolongation, syncope, and nonsustained ventricular tachycardia.
- These cardiac events were associated with high-dose cisapride therapy.
Findings:
- High-dose cisapride can induce potentially life-threatening cardiac arrhythmias.
- The drug's proarrhythmic effects warrant careful consideration, especially at elevated dosages.
Implications:
- This case underscores the importance of monitoring cardiac function in patients receiving high-dose cisapride.
- Clinicians should be aware of the potential for cisapride-induced QT prolongation and ventricular tachycardia.
- Risk-benefit assessment is crucial when prescribing cisapride, particularly in vulnerable patient populations.
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