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[Sumatriptan and cluster headache]

A Moreno1, V Serrano, J L Casado

  • 1Servicio de Neurología, Hospital Universitario Virgen del Rocío, Sevilla.

Neurologia (Barcelona, Spain)
|February 1, 1995
PubMed
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Subcutaneous sumatriptan offers rapid relief for cluster headache (CH) attacks, with patients preferring it over other treatments. While effective and well-tolerated, its high cost is a consideration for daily use in CH symptom management.

Area of Science:

  • Neurology
  • Pharmacology

Context:

  • Cluster headache (CH) is a debilitating neurological disorder.
  • Established efficacy of sumatriptan in double-blind studies.
  • Limited data on daily subcutaneous sumatriptan use for CH.

Purpose:

  • To evaluate the efficacy, tolerance, and appropriateness of daily subcutaneous sumatriptan for CH treatment.
  • To compare sumatriptan's effectiveness with other CH therapies.

Summary:

  • An open trial assessed subcutaneous sumatriptan in 16 patients over 232 CH attacks.
  • Sumatriptan demonstrated rapid onset of action, with pain diminishing in a mean of 9 minutes and severe pain resolving within 15 minutes.
  • All patients preferred sumatriptan, reporting high satisfaction and no serious side effects, deeming it a first-choice CH medication despite its cost.

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Impact:

  • Subcutaneous sumatriptan is a highly effective and preferred treatment for acute cluster headache attacks.
  • The rapid relief and good tolerance profile support its use, though cost remains a factor.
  • Findings provide valuable insights for managing CH symptoms with sumatriptan.