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Positive interference of merthiolate in the TDx digoxin assay in control samples used in the Belgian External Quality
N Devleeschouwer1, J C Libeer, J Schiettecatte
1Department of Clinical Biology, Institut of Hygiene and Epidemiology, Brussels, Belgium.
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|December 1, 1994
Abstract:
We investigated the possible origin of the spuriously high results observed with the Abbott TDx Immunoassay in the 1991 Belgian external quality assessment scheme for digoxin. The present work ascribes this discrepancy to a matrix effect induced by the addition of merthiolate as preservative to the control samples. It consequently stresses the importance of avoiding the use of this compound for preparing such samples.