[The anti-arrhythmic activity of quinuclidine derivatives]

Experiments on conscious rabbits have shown that the quinuclidine bicarphene displays a sufficiently profound antiarrhythmic activity. The agent, 1.0 mg/kg, prevents and abolishes arrhythmias induced by calcium chloride, strophanthin, and epinephrine and fails to affect the cardiac arrhythmias caused by aconitine and barium chloride. Higher bicarphene doses (1.5-2.0 mg/kg) results in severe bradycardia in intact rabbits, slower atrioventricular conduction. It is suggested that the antiarrhythmic activity of bicarphene is associated with its effects on cardiomyocytic membranous Ca2+ transport.