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Bladder contractility and idiopathic detrusor instability in males
1Divisione di Urologia, Policlinico S. Matteo, Pavia, Italy.
Neurourology and Urodynamics
|January 1, 1994
Summary
Idiopathic detrusor instability in men shows increased detrusor shortening velocity, suggesting enhanced bladder muscle contractility. This may indicate an early stage of the condition, differing from later phases involving impaired function.
Area of Science:
- Urology
- Physiology
Background:
- Idiopathic detrusor instability is a common condition affecting bladder function.
- Previous studies suggest altered detrusor contractility in unstable bladders.
Purpose of the Study:
- To investigate detrusor contractility in men with idiopathic detrusor instability.
- To explore the potential mechanisms underlying detrusor instability.
Main Methods:
- Urodynamic assessment of thirty males with idiopathic detrusor instability.
- Comparison with thirty age-matched healthy controls.
- Measurement of detrusor shortening velocity and urethral resistance.
Main Results:
- Increased detrusor shortening velocity was observed in patients with detrusor instability (P < 0.001).
- Enhanced contractile capability was inferred, with normal urethral resistance.
- Findings align with previous research in both male and female patients.
Conclusions:
- Detrusor instability may involve increased excitability and electrical coupling of bladder smooth muscle cells.
- Enhanced contractility could represent an early phase in the natural history of detrusor instability.
- This contrasts with later stages potentially involving detrusor collagenosis and impaired function.