The role of the Schwann cell in trophic support and regeneration

Schwann cells show remarkable versatility in undertaking a broad repertoire of functions. Ensheathment and myelination are specifically regulated by contact with axons, and the Schwann cell is centrally involved in extracellular matrix production in the peripheral nerve trunk. Additional Schwann cell functions include the promotion of both peripheral and central nervous system regeneration, provision of a versatile source of trophic factors, the capacity to remyelinate central nervous system axons, and the restoration of electrophysiological conduction. Since it is now possible to isolate Schwann cells both from neonatal and adult human peripheral nerve, their ability to promote regenerative efforts by many central neurons suggests a role for Schwann cell autografts in influencing central nervous system repair.