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Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients
I Garcia-de la Torre1, J Castello-Sendra, T Esgleyes-Ribot
1Department of Immunology and Rheumatology, Hospital General de Occidente de la Secretaria de Salud, Zapopan, Mexico.
Objective:
To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS).
Methods:
Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed.
Results:
ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients.
Conclusion:
The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.