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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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[A case of pulmonary infiltrates associated with a neutrophil-specific antibody transfusion reactions]

K Kan1, C Tase, H Ohto

  • 1Department of Anesthesiology, Fukushima Medical College.

Masui. the Japanese Journal of Anesthesiology
|January 1, 1995
PubMed

A normovolemic pulmonary edema associated with blood transfusion developed in a 38-year-old woman during gynecological operation. Bilateral pulmonary infiltrates and profound leucopenia (700.microliters-1) were observed. An antibody reactive with the recipient's neutrophils was found in a donor and an antibody reacting with the lymphocytes of the recipient was identified in another donor. Both donors were multiparous women. Respiratory failure was improved with mechanical ventilation but chest X-ray showed pulmonary infiltrates for the next 3 days. The white blood cell count rose to 2900.microliters-1 in the next day, and it took 2 weeks to be normalized. Transient pulmonary infiltrates can be caused by antileukocyte antibodies passively transfused by multiparous donors.

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