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A proposed strategic research program for Alzheimer's disease
1Department of Neurology, University of Minnesota Medical School, Minneapolis 55455.
Neurobiology of Aging
|January 1, 1994
Summary
Future Alzheimer's disease (AD) research in the U.S. should prioritize aging-related studies. The National Institute of Aging (NIA) should focus funding on understanding the role of age in AD pathogenesis.
Area of Science:
- Neuroscience
- Gerontology
- Genetics
Background:
- Alzheimer's disease (AD) research requires strategic prioritization.
- Existing research has identified key areas for future investigation.
Purpose of the Study:
- To recommend four key priorities for U.S. Alzheimer's disease research over the next decade.
- To guide the National Institute of Aging (NIA) funding towards age-related AD studies.
Main Methods:
- Review of current literature on Alzheimer's disease.
- Analysis of ongoing studies and development of transgenic animal models.
- Integration of aging research with molecular biology and genetics of AD.
Main Results:
- Four priority areas for AD research: complete transgenic models, integrate aging and genetics, reexamine plaques/tangles, and investigate APP's age-dependent role.
- Emphasis on age-dependent mechanisms in AD pathogenesis.
- A tiered funding approach prioritizing aging-related studies.
Conclusions:
- NIA funding should concentrate on research directly linked to the role of age and aging in AD.
- Aging-related studies should form the core of the NIA's future AD research agenda.
- Non-aging-related approaches should receive secondary funding consideration.