Targets for Alzheimer's disease research: from basic mechanisms to rational therapies

Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques.

Cardiovascular engineering and technology·2020

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.

PloS one·2018

Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

Translational psychiatry·2016

Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Molecular psychiatry·2015

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Molecular psychiatry·2014

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

Translational psychiatry·2014

Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.

Neurobiology of aging·2026

Age-related differences in resting and event-evoked ocular response dynamics.

Neurobiology of aging·2026

Genetic architecture of Alzheimer's disease-related plasma biomarkers.

Neurobiology of aging·2026

The role of cognitive-motor interaction in landmark reliance and navigational deficits in older adults.

Neurobiology of aging·2026

Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans.

Neurobiology of aging·2026

Sex-specificities in the association between social network and cognition in older individuals.

Neurobiology of aging·2026

Analysis of biological systems using bioimpedance spectroscopy: a critical review of technological convergence and translational challenges.

Frontiers in bioengineering and biotechnology·2026

A unified analysis of cell-type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026

Systems Biology and Atomistic Simulations Reveal Multi-Target Modulation of Alzheimer's Disease and Type 2 Diabetes by Caesalpinia sappan Bioactives.

International journal of molecular sciences·2026

Stoichiometric balance and sustained rhythms.

Journal of mathematical biology·2026

SREBPs in Metabolic Reprogramming and Disease: Mechanisms and Therapeutic Potential.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Learning dynamical systems with biochemically informed neural ordinary differential equations.

bioRxiv : the preprint server for biology·2026

Related Experiment Videos

Targets for Alzheimer's disease research: from basic mechanisms to rational therapies

Related Concept Videos

Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques.

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.

Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.

Age-related differences in resting and event-evoked ocular response dynamics.

Genetic architecture of Alzheimer's disease-related plasma biomarkers.

The role of cognitive-motor interaction in landmark reliance and navigational deficits in older adults.

Amyloid-associated cognitive trajectories in aging dogs mirror early changes in humans.

Sex-specificities in the association between social network and cognition in older individuals.

Analysis of biological systems using bioimpedance spectroscopy: a critical review of technological convergence and translational challenges.

A unified analysis of cell-type- and trajectory-associated pathways in single-cell data using Phoenix.

Systems Biology and Atomistic Simulations Reveal Multi-Target Modulation of Alzheimer's Disease and Type 2 Diabetes by Caesalpinia sappan Bioactives.

Stoichiometric balance and sustained rhythms.

SREBPs in Metabolic Reprogramming and Disease: Mechanisms and Therapeutic Potential.

Learning dynamical systems with biochemically informed neural ordinary differential equations.

Related Experiment Videos

Targets for Alzheimer's disease research: from basic mechanisms to rational therapies

Related Concept Videos

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