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Updated: Sep 8, 2026

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Published on: February 15, 2016
Structural and electronic conditions for anticonvulsant activity of bicyclic hydantoin derivatives
J Karolak-Wojciechowska1, W Kwiatkowski, K Kiec-Kononowicz
1Institute of General and Ecological Chemistry, Technical University, Lodź, Poland.
Abstract:
A series of bicyclic derivatives based on 5,5-diphenylhydantoin (DPH) and/or 5-arylidene-hydantoin skeletons (BZH) are discussed as potential anticonvulsants. In preliminary pharmacological tests a few of these agents showed some anticonvulsant activities, like the parent DPH. The electronic parameters (molecular electrostatic potential, MEP, and dipole moment orientation) for the DPH molecule used as a model differed significantly from those calculated for the bicyclic molecules. These parameters were derived from semiempirical quantum chemistry calculations applying the PM3 method.
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