[Digital necrosis disclosing antisynthetase syndrome]

Area of Science:

• Rheumatology
• Immunology
• Dermatology

Background:

• Antisynthetase syndrome is an autoimmune disorder associated with lung disease, polymyositis, Raynaud's phenomenon, and polyarthritis.
• The presence of anti-aminoacyl-tRNA synthetase antibodies, most commonly anti-Jol, defines the syndrome.

Observation:

• A case presented with severe finger arteritis and multiple zones of skin necrosis.
• This severe presentation occurred alongside classical Raynaud's phenomenon.

Findings:

• The patient's condition showed a favorable response to high-dose corticosteroids and cyclophosphamide.
• Finger arteritis with skin necrosis is proposed as a potential new manifestation of antisynthetase syndrome.

Implications:

• This finding expands the spectrum of clinical manifestations associated with antisynthetase syndrome.
• Early recognition and aggressive treatment of finger arteritis may be crucial for managing patients with this syndrome.