The effect of bacterial adjuvants on Trypanosoma lewisi infections in rats

The effect of Escherichia coli endotoxin, B.C.G. vaccine and Bordetella pertussis vaccine on the parasitemia of Trypanosoma lewisi was studied in rats. It was found that in general, B. pertussis administration resulted in higher and more prolonged parasitemias than normal. In contrast E. coli endotoxin tended to reduce both the intensity and duration of parasitemia. Possible reasons for this phenomenon are discussed.