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[Immunity to measles, mumps and rubella in children vaccinated with triple viral vaccine]

F J Pisón Garcés1, J Galbe Sánchez-Ventura, P Arcauz Eguren

  • 1Centro de Salud Oliver-Miralbueno, Zaragoza.

Atencion Primaria
|March 15, 1995
PubMed

Insights

Measles-mumps-rubella (MMR) vaccination provides significant protection, but this study found a notable percentage of vaccinated children had low antibody levels for measles, mumps, and rubella.

Area of Science:

  • Pediatrics
  • Immunology
  • Vaccinology

Background:

  • The Measles-Mumps-Rubella (MMR) vaccine is a cornerstone of childhood immunization programs worldwide.
  • Ensuring sustained immunity post-vaccination is critical for maintaining disease control.

Purpose of the Study:

  • To assess the serological status of measles-mumps-rubella immunity in children vaccinated with the MMR vaccine.
  • To identify the prevalence of seronegativity for measles, mumps, and rubella in a pediatric cohort.

Main Methods:

  • A descriptive cross-sectional study employing a seroepidemiological survey.
  • Involved 92 healthy children aged 5, 7, and 9 years attending a health center for preventive services.
  • Participants had received the MMR vaccine between 15-18 months of age and had no history of measles, mumps, or rubella.

Main Results:

  • A significant proportion of vaccinated children exhibited seronegativity: 9.8% for measles, 8.7% for rubella, and 27.2% for mumps.
  • Analysis also considered differences in antibody levels based on time since vaccination.

Conclusions:

  • The study highlights a concerning percentage of MMR-vaccinated children with minimal or undetectable antibody levels.
  • These findings suggest potential waning immunity and underscore the importance of monitoring vaccine effectiveness.
Abstract

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