Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic hepatitis in experimental schistosomiasis

Z A Andrade1, A W Cheever

  • 1Gonçalo Moniz Research Center, Salvador, Bahia, Brazil.

Virchows Archiv : an International Journal of Pathology
|January 1, 1995
PubMed
Summary

Schistosomiasis infection in animal models can cause chronic hepatitis, challenging the assumption that viral infections are the sole cause in humans. This study reveals the liver

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunocytochemical Studies in Schistosomiasis.

The American journal of pathology·2009
Same author

Schistosomiasis and liver fibrosis.

Parasite immunology·2009
Same author

Biomphalaria tenagophila/Schistosoma mansoni interaction: premises for a new approach to biological control of schistosomiasis.

Memorias do Instituto Oswaldo Cruz·2004
Same author

Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni.

Parasitology research·2004
Same author

Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2003
Same author

The study of T-cell activation in peripheral blood and spleen of hepatosplenic patients suggests an exchange of cells between these two compartments in advanced human Schistosomiasis mansoni infection.

Scandinavian journal of immunology·2002

Area of Science:

  • Hepatology
  • Parasitology
  • Immunology

Background:

  • Schistosomiasis is a parasitic disease with significant global health implications.
  • The liver is a primary target organ for schistosome parasites.
  • The role of schistosomiasis in inducing chronic liver disease is not fully understood.

Purpose of the Study:

  • To investigate the potential of Schistosoma mansoni and Schistosoma japonicum infections to induce chronic hepatitis in experimental models.
  • To characterize the histological changes associated with schistosomiasis-induced liver inflammation.
  • To evaluate the persistence of hepatic inflammation after parasite clearance.

Main Methods:

  • Histological examination of liver tissues from infected mice, rabbits, and non-human primates.
  • Infection with Schistosoma mansoni and Schistosoma japonicum.
  • Observation of pathological changes over time and after chemotherapy.

Main Results:

  • Schistosome egg deposition caused reactive hepatitis in early infection.
  • Persistent portal and septal cellular infiltrations were observed long after parasite activity diminished.
  • Chronic active hepatitis and progression to cirrhosis were noted in rabbits.

Conclusions:

  • Schistosomiasis has the potential to induce chronic hepatitis.
  • The findings suggest that schistosomiasis itself, not solely co-infection with viruses, may cause chronic hepatitis in humans.
  • The established assumption linking chronic hepatitis in schistosomiasis patients solely to viral infections warrants re-evaluation.

Related Experiment Videos