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Urinary selenium concentrations in heroin abusers

E M Rodríguez Rodríguez1, M Sanz Alaejos, C Díaz Romero

  • 1Department of Analytical Chemistry, Food Science and Toxicology, University of La Laguna, Spain.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 1, 1994
PubMed
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Heroin abusers have significantly lower urinary selenium levels compared to healthy individuals. Methadone treatment did not alter these selenium concentrations in abusers.

Area of Science:

  • Environmental Health
  • Toxicology
  • Nutritional Science

Background:

  • Selenium (Se) is an essential trace element crucial for various physiological functions.
  • Substance abuse, particularly heroin use, may impact nutritional status and trace element levels.
  • Urinary selenium concentration serves as a biomarker for recent selenium exposure and status.

Purpose of the Study:

  • To investigate urinary selenium concentrations in heroin abusers compared to healthy controls.
  • To explore the relationship between age, heroin use duration, and urinary selenium levels.
  • To assess the effect of methadone treatment on urinary selenium concentrations in heroin abusers.

Main Methods:

  • Urinary samples were collected from heroin abusers and healthy controls.

Related Experiment Videos

  • Urinary selenium concentrations were measured in micrograms per liter (µg/L) and micrograms per gram of creatinine (µg/g creatinine).
  • Statistical analyses were performed to compare groups and assess correlations.

    • Main Results:

    • Heroin abusers exhibited significantly lower urinary selenium concentrations (both µg/L and µg/g creatinine) than healthy controls (P < 0.050).
    • A negative correlation was observed between age and urinary selenium concentration (µg/g creatinine) in heroin abusers, potentially linked to cumulative heroin exposure.
    • No significant differences in urinary selenium concentrations were found between heroin abusers undergoing methadone treatment and those who had ceased the drug, relative to controls (P > 0.100).

    Conclusions:

    • Heroin abuse is associated with reduced urinary selenium levels, indicating a potential depletion or altered metabolism of this essential trace element.
    • Age and duration of heroin use may influence selenium status, suggesting cumulative exposure effects.
    • Methadone treatment does not appear to significantly alter urinary selenium concentrations in heroin abusers compared to untreated abusers or controls.