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CD40 ligand is functionally expressed on human eosinophils

J F Gauchat1, S Henchoz, D Fattah

  • 1Glaxo Institute for Molecular Biology, Plan les Ouates/Geneva, Switzerland.

European Journal of Immunology
|March 1, 1995
PubMed
Summary
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CD40 ligand (CD40L) is expressed by eosinophils, which can promote B cell proliferation. This finding suggests a role for eosinophils and CD40L in inflammatory conditions.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD40 ligand (CD40L) is a molecule expressed on immune cells like T cells, mast cells, and basophils.
  • CD40L plays a key role in B cell proliferation, immunoglobulin class switching, and monocyte/T cell activation.

Purpose of the Study:

  • To investigate the expression of CD40L by eosinophils.
  • To determine the functional role of eosinophil-derived CD40L in B cell activation.

Main Methods:

  • Analysis of CD40L expression on eosinophils from a hypereosinophilic patient and an eosinophilic cell line (EOL-3).
  • In vitro experiments assessing the ability of activated normal blood eosinophils to induce B cell proliferation in the presence of IL-4.

Main Results:

  • CD40L was constitutively expressed by eosinophils from a hypereosinophilic patient.

Related Experiment Videos

  • Activated eosinophils (EOL-3 cell line and normal blood eosinophils) also expressed CD40L.
  • Eosinophils, in conjunction with IL-4, induced CD40L-dependent B cell proliferation in vitro.

    • Conclusions:

    • Eosinophils can express CD40L, both constitutively in disease and upon activation.
    • Eosinophil-derived CD40L contributes to B cell proliferation, suggesting a role in inflammatory processes involving eosinophils.