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Stable antiviral expression (SAVE) as an approach to somatic cell gene therapy directed against HIV infection
E De Maeyer1, I Seif, V Vieillard
1CNRS-URA 1343, Institut Curie, Centre Universitaire, Orsay, France.
[Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
|November 1, 1994
Abstract:
We are developing methods for somatic cell gene therapy directed against infection with human immunodeficiency virus by enhancing the antiviral resistance of target cells through the constitutive production of interferon-beta. Cells that have been transformed by plasmids or retroviral vectors carrying the human interferon-beta gene placed under the expression control of a murine H2Kb promoter fragment become resistant to HIV infection. Part of this enhanced resistance is due to inhibition of virus entry into the transformed cells, a hitherto unreported mechanism of interferon action.