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Pharmacodynamic interactions of omeprazole with CNS active drugs in rats
S M Chandrashekhar1, A Chakrabarti, S K Garg
1Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Indian Journal of Physiology and Pharmacology
|January 1, 1995
Abstract:
A pharmacodynamic interactional study with omeprazole was undertaken in rats. Omeprazole (7 mg/kg, orally once daily for 14 days) significantly prolonged pentobarbitone (30 mg/kg, ip) induced hypnosis while it had no effect on haloperidol (1 mg/kg, ip) induced catalepsy or morphine (5 mg/kg, ip) induced analgesia models in rats. The study highlighted the fact that dynamic interaction with omeprazole was selective.