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Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro
C Bonne-Andrea1, S Santucci, P Clertant
1Centre de Biochimie, Unité 273 de l'Institut National de la Santé et de la Recherche Médicale, Nice, France.
Journal of Virology
|May 1, 1995
Abstract:
Bovine papillomavirus E1 protein was found to be as efficient as the simian virus 40 large T antigen in initiating DNA synthesis in a cell-free system derived from COS1 cells. Multiple rounds of DNA synthesis occur, initiated at the bovine papillomavirus type 1 origin. Therefore, E1 functions in vitro as a lytic virus initiator.