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Tuberous sclerosis
1Division of Pediatric Neurology, University of Texas Southwestern Medical School, Dallas, USA.
Dermatologic Clinics
|January 1, 1995
Abstract:
Tuberous sclerosis complex is a disorder of cellular differentiation and proliferation that is inherited as an autosomal dominant trait with variable penetrance and a high spontaneous mutation rate. Lesions occur in the brain, skin, kidneys, heart, and other organs. Recent studies suggest genetic heterogeneity, with at least two gene loci on chromosomes 9, 16, and perhaps 11.