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[Iatrogenic osteoporsis: six case reports]

L M Zheng1, J Z Wang

  • 1Tianjin Medical University.

Zhonghua Nei Ke Za Zhi
|October 1, 1994
PubMed
Summary
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Glucocorticosteroid-induced osteoporosis can be reversed in patients with conditions like asthma and arthritis. Treatment with alternate-day hormone therapy, calcium, and vitamin D improved bone mineral density and biochemistry.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Pulmonology

Context:

  • Iatrogenic osteoporosis is a common secondary condition.
  • Patients treated with long-term, high-dose glucocorticosteroids are at high risk.
  • This study examines six cases of glucocorticosteroid-induced osteoporosis.

Purpose:

  • To evaluate the efficacy of alternate-day hormone therapy combined with calcium and vitamin D in managing iatrogenic osteoporosis.
  • To assess the impact of this treatment regimen on bone mineral content and biochemical markers.

Summary:

  • Six patients (27-46 years old) with conditions like asthma, rheumatoid arthritis, skin disease, and collagenosis received glucocorticosteroids for 1-3.5 years.
  • Five patients were treated with prednisone (5-30mg daily) and one with dexamethasone (0.75g daily).

Related Experiment Videos

  • After one year of alternate-day hormone therapy, calcium, and vitamin D supplementation, all patients showed improved bone mineral content and biochemistry.

    • Impact:

    • This therapeutic approach demonstrates potential for reversing bone loss and improving metabolic parameters in patients with iatrogenic osteoporosis.
    • Highlights the importance of monitoring bone health in patients on long-term glucocorticosteroid therapy.
    • Suggests a viable treatment strategy to mitigate the adverse skeletal effects of glucocorticosteroids.