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Related Experiment Videos

Immunoregulation and autoimmunity

J D Stobo, C P Loehnen

    Mayo Clinic Proceedings
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Immunologic responses involve a balance of forces that regulate T and B cells. Aberrant immunoregulation may cause autoimmune diseases like systemic lupus erythematosus.

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    Area of Science:

    • Immunology
    • Autoimmunity
    • Cellular immunology

    Background:

    • Immunologic responses to external antigens are regulated by forces that augment or suppress T and B effector cell activity.
    • Similar regulatory mechanisms likely maintain tolerance to self-antigens.
    • A lack of autoimmunity may result from insufficient amplification or excessive suppression of immune responses.

    Purpose of the Study:

    • To discuss data on immunoregulation abnormalities in systemic lupus erythematosus (SLE).
    • To explore the potential causal relationship between these abnormalities and the autoimmune nature of SLE.

    Main Methods:

    • Review of existing data on immunoregulation in SLE patients.
    • Analysis of the role of immune regulatory forces in maintaining self-tolerance.

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    Main Results:

    • Systemic lupus erythematosus (SLE) is characterized by aberrations in immunoregulation.
    • These aberrations are potentially linked to the disease's autoimmune mechanisms.

    Conclusions:

    • Dysregulation of immune responses, including T and B cell activity, is implicated in autoimmunity.
    • Specific immunoregulation defects may drive the pathogenesis of systemic lupus erythematosus (SLE).