Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in antitumor antibiotics

H Umezawa

    Antibiotics and Chemotherapy
    |January 1, 1978
    PubMed
    Summary

    New cancer treatment strategies leverage bleomycin combinations and novel anthracycline antibiotics. Research explores bleomycin derivatives and microbial metabolites for improved antitumor efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Synthesis and antitumor activity of 4'-O-acylanthracyclines.

    The Journal of antibiotics·1992
    Same author

    Ascorbic acid and adriamycin toxicity.

    The American journal of clinical nutrition·1991
    Same author

    Synthesis of 3'-deoxy-3'-fluorokanamycin A and 3',4'-dideoxy-3'-fluorokanamycin A.

    Carbohydrate research·1991
    Same author

    High-performance liquid chromatographic determination of deoxyspergualin in dog plasma with ultraviolet detection.

    Journal of chromatography·1990
    Same author

    Post-ischaemic treatment with the prostacycline analogue TTC-909 reduces ischaemic brain injury.

    Acta neurochirurgica. Supplementum·1990
    Same author

    Local cerebral blood flow and glucose metabolism in hydrostatic brain oedema.

    Acta neurochirurgica. Supplementum·1990

    Area of Science:

    • * Oncology
    • * Microbiology
    • * Pharmacology

    Background:

    • * Current cancer treatments often involve combination chemotherapy.
    • * Bleomycin and anthracyclines are established antitumor antibiotics.
    • * Development of novel derivatives and analogues is crucial for enhanced efficacy.

    Purpose of the Study:

    • * To introduce effective treatment schedules using bleomycin and mitomycin.
    • * To explore neocarzinostatin as a novel therapeutic agent.
    • * To investigate new bleomycin derivatives and anthracycline antitumor antibiotics.

    Main Methods:

    • * Clinical studies on combination chemotherapy regimens.
    • * Isolation and testing of microbial secondary metabolites, including aclacinomycin and anthracycline glycosides from beer fermentation.
    • * Evaluation of bleomycin derivatives and analogues.

    Main Results:

    • * An effective treatment schedule with bleomycin and mitomycin was identified.
    • * Neocarzinostatin showed promise as a new treatment agent.
    • * Bleomycin PEP was selected as a potentially useful agent.
    • * Aclacinomycin and other anthracycline glycosides were isolated and tested.

    Conclusions:

    • * Combination therapy with bleomycin and mitomycin offers an effective treatment option.
    • * Neocarzinostatin represents a new area in cancer treatment.
    • * Further development of bleomycin analogues and microbial metabolites holds promise for future cancer therapies.

    Related Experiment Videos