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Chemical incompatibility between procainamide hydrochloride and glucose following intravenous admixture
A Sianipar1, J E Parkin, V B Sunderland
1School of Pharmacy, Curtin University of Technology, Perth, Australia.
The Journal of Pharmacy and Pharmacology
|December 1, 1994
Abstract:
The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. Substantial amounts (10-15% after 10 h at room temperature) of the procainamide is lost with the formation of a mixture of the corresponding alpha- and beta-glucosylamines. The chemical identity of the latter compounds was confirmed by 13C and 1H nuclear magnetic resonance spectroscopy.