Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Buccal mucosal urethral replacement

J W Duckett1, D Coplen, D Ewalt

  • 1Division of Urology, Children's Hospital of Philadelphia, Pennsylvania, USA.

The Journal of Urology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An evaluation of the readability, quality, and accuracy of online health information regarding the treatment of hypospadias.

Journal of pediatric urology·2018
Same author

Predictors of becoming overweight among pediatric patients at risk for urinary tract infections.

Journal of pediatric urology·2018
Same author

The power and perils of animal models with urogenital anomalies: handle with care.

Journal of pediatric urology·2014
Same author

Hypospadias: interactions between environment and genetics.

Molecular and cellular endocrinology·2011
Same author

Surgical treatment of congenital hypertrophic pyloric stenosis.

Texas state journal of medicine·2010
Same author

Resection of primary liver tumors.

Surgery·2010
Same journal

Editorial Comment.

The Journal of urology·2026
Same journal

Editorial Comment.

The Journal of urology·2026
Same journal

Editorial Comment.

The Journal of urology·2026
Same journal

Uro-Science.

The Journal of urology·2026
Same journal

Editorial Comment.

The Journal of urology·2026
Same journal

Editorial Comment.

The Journal of urology·2026
See all related articles

Buccal mucosa offers a promising alternative for urethral reconstruction, showing fewer complications than traditional grafts. This tissue may improve graft success in complex cases.

Area of Science:

  • Urology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Traditional grafts for urethral replacement (skin, bladder mucosa) often lead to complications like meatal prolapse, stricture, and fistula.
  • Effective urethral substitution is crucial when local tissue is insufficient for reconstruction.

Purpose of the Study:

  • To evaluate the clinical efficacy and outcomes of using buccal mucosa for urethral substitution over an 8-year period.
  • To compare the histological characteristics of buccal mucosa grafts with traditional skin grafts for urethral reconstruction.

Main Methods:

  • Retrospective review of 18 urethral reconstructions using buccal mucosa grafts.
  • Cases included exstrophy/epispadias, complex hypospadias repairs, and bulbar urethral strictures.
  • Histological analysis compared buccal mucosa and skin grafts, focusing on graft thickness and vascularity.

Related Experiment Videos

Main Results:

  • Out of 18 cases, 5 experienced meatal stenosis (2 requiring revision), with no cases of meatal eversion.
  • One urethrocutaneous fistula and one mid-graft stricture were observed.
  • Buccal mucosa grafts demonstrated thinner dermal/lamina propria layers and greater vascularity compared to skin grafts.

Conclusions:

  • Buccal mucosa is a viable and effective tissue for urethral substitution, associated with a lower complication rate than previously used grafts.
  • Superior graft take and encouraging clinical results are attributed to the histological advantages of buccal mucosa, including its vascularity and thinness.