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Sympathetic sudomotor function and aging

T Ferrer1, M J Ramos, P Pérez-Sales

  • 1Department of Neurophysiology, La Paz General Hospital, Madrid, Spain.

Muscle & Nerve
|April 1, 1995
PubMed
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Sweat gland density (SGD) significantly decreases with age in both hands and feet. The foot is the best site for assessing aging effects on sweating, with specific density limits provided for different age groups.

Area of Science:

  • Physiology
  • Autonomic Nervous System Research
  • Dermatology

Background:

  • Aging impacts autonomic nervous system components, but less is known about the sympathetic cholinergic system.
  • Sudomotor function, controlled by the sympathetic nervous system, is crucial for thermoregulation.

Purpose of the Study:

  • To evaluate postganglionic sudomotor function by assessing sweat gland density (SGD) in relation to aging.
  • To determine the most appropriate body site for examining age-related changes in sweating.
  • To establish normative values for foot SGD across different age groups.

Main Methods:

  • Assessed sweat gland density (SGD) using the impression mold technique on the dorsum of the hand and foot.
  • Studied 196 healthy individuals (104 women, 92 men) aged 5 to 84 years.

Related Experiment Videos

  • Utilized ANOVA to analyze the influence of age, sex, and body surface area on SGD.

    • Main Results:

    • A significant decrease in SGD was observed with increasing age on both the hand and foot (P < 0.001).
    • Age was the sole significant factor affecting SGD reduction on the foot.
    • On the hand, age, sex, and body surface area were significant covariates influencing SGD.

    Conclusions:

    • The dorsum of the foot is the most suitable location for studying age-related changes in sweating.
    • Established age-specific lower normal limits for foot SGD: <30 years (213/cm2), 30-59 years (199/cm2), and >59 years (123/cm2).
    • Findings highlight the impact of aging on sudomotor function and provide valuable reference data.